Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat o...
Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat of Adenomatous Polyposis Coli
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Wnt signalling is prevented by the proteosomal degradation of β-catenin, which occurs in a destruction complex containing adenomatous polyposis coli (APC), APC-like (APCL), Axin and Axin2. Truncating mutations of the APC gene result in the constitutive stabilisation of β-catenin and the initiation of colon cancer, although tumour cells tolerate the...
Alternative Titles
Full title
Different Roles for the Axin Interactions with the SAMP versus the Second Twenty Amino Acid Repeat of Adenomatous Polyposis Coli
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TN_cdi_plos_journals_1514809091
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1514809091
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0094413
