Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli...
Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase
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Author / Creator
Wang, Qian , Qi, Yifei , Yin, Ning and Lai, Luhua
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
D-3-phosphoglycerate dehydrogenase (PGDH) from Escherichia coli catalyzes the first critical step in serine biosynthesis, and can be allosterically inhibited by serine. In a previous study, we developed a computational method for allosteric site prediction using a coarse-grained two-state Gō Model and perturbation. Two potential allosteric sites we...
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Full title
Discovery of novel allosteric effectors based on the predicted allosteric sites for Escherichia coli D-3-phosphoglycerate dehydrogenase
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TN_cdi_plos_journals_1516462689
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1516462689
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0094829
