Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-sp...
Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages
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Author / Creator
Bility, Moses T , Cheng, Liang , Zhang, Zheng , Luan, Yan , Li, Feng , Chi, Liqun , Zhang, Liguo , Tu, Zhengkun , Gao, Yanhang , Fu, Yangxin , Niu, Junqi , Wang, Fusheng and Su, Lishan
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood due to a lack of a robust small animal model. Here we report the development of a humanized mouse model with both human immune system and human liver cells by reconstituting the immunodeficient A2/NSG (NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ mice with human HLA-A2 tra...
Alternative Titles
Full title
Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages
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Record Identifier
TN_cdi_plos_journals_1516750440
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1516750440
Other Identifiers
ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1004032
