Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
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Author / Creator
Macdonald, Douglas , Tessari, Michela A. , Boogaard, Ivette , Smith, Melanie , Pulli, Kristiina , Szynol, Agnieszka , Albertus, Faywell , Lamers, Marieke B. A. C. , Dijkstra, Sipke , Kordt, Daniel , Reindl, Wolfgang , Herrmann, Frank , McAllister, George , Fischer, David F. and Munoz-Sanjuan, Ignacio
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The expansion of a CAG trinucleotide repeat in the huntingtin gene, which produces huntingtin protein with an expanded polyglutamine tract, is the cause of Huntington's disease (HD). Recent studies have reported that RNAi suppression of polyglutamine-expanded huntingtin (mutant HTT) in HD animal models can ameliorate disease phenotypes. A key requi...
Alternative Titles
Full title
Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1522948415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1522948415
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0096854
