Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Li...
Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Dynorphins, endogenous opioid peptides that arise from the precursor protein prodynorphin (Pdyn), are hypothesized to be involved in the regulation of mood states and the neuroplasticity associated with addiction. The current study tested the hypothesis that dynorphin in the nucleus accumbens (NAcc) mediates such effects. More specifically, we exam...
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Full title
Virus-Mediated shRNA Knockdown of Prodynorphin in the Rat Nucleus Accumbens Attenuates Depression-Like Behavior and Cocaine Locomotor Sensitization
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TN_cdi_plos_journals_1522948432
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1522948432
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0097216
