The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B
The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric inhibitors containing a benzofuran sulfonamide sc...
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Full title
The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B
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TN_cdi_plos_journals_1524876170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1524876170
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0097668
