A Central Role for GRB10 in Regulation of Islet Function in Man
A Central Role for GRB10 in Regulation of Islet Function in Man
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Author / Creator
Prokopenko, Inga , Poon, Wenny , Mägi, Reedik , Prasad B, Rashmi , Salehi, S. Albert , Almgren, Peter , Osmark, Peter , Bouatia-Naji, Nabila , Wierup, Nils , Fall, Tove , Stančáková, Alena , Barker, Adam , Lagou, Vasiliki , Osmond, Clive , Xie, Weijia , Lahti, Jari , Jackson, Anne U. , Cheng, Yu-Ching , Liu, Jie , O'Connell, Jeffrey R. , Blomstedt, Paul A. , Fadista, Joao , Alkayyali, Sami , Dayeh, Tasnim , Ahlqvist, Emma , Taneera, Jalal , Lecoeur, Cecile , Kumar, Ashish , Hansson, Ola , Hansson, Karin , Voight, Benjamin F. , Kang, Hyun Min , Levy-Marchal, Claire , Vatin, Vincent , Palotie, Aarno , Syvänen, Ann-Christine , Mari, Andrea , Weedon, Michael N. , Loos, Ruth J. F. , Ong, Ken K. , Nilsson, Peter , Isomaa, Bo , Tuomi, Tiinamaija , Wareham, Nicholas J. , Stumvoll, Michael , Widen, Elisabeth , Lakka, Timo A. , Langenberg, Claudia , Tönjes, Anke , Rauramaa, Rainer , Kuusisto, Johanna , Frayling, Timothy M. , Froguel, Philippe , Walker, Mark , Eriksson, Johan G. , Ling, Charlotte , Kovacs, Peter , Ingelsson, Erik , McCarthy, Mark I. , Shuldiner, Alan R. , Silver, Kristi D. , Laakso, Markku , Groop, Leif , Lyssenko, Valeriya , Strategiska forskningsområden (SFO) , Translationell muskelforskning , Department of Experimental Medical Science , Neuroendocrine Cell Biology , Department of Laboratory Medicine , EpiHealth: Epidemiology for Health , Diabetes - epigenetik , Strategic research areas (SRA) , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Institutionen för laboratoriemedicin , Profile areas and other strong research environments , Department of Clinical Sciences, Malmö , Neuroendokrin cellbiologi , Faculty of Medicine , Medicinska fakulteten , Diabetes - Epigenetics , Institutionen för kliniska vetenskaper, Malmö , Internal Medicine - Epidemiology , Lunds universitet , Translational Muscle Research , Profilområden och andra starka forskningsmiljöer , Division of Molecular Medicine and Gene Therapy , Institutionen för experimentell medicinsk vetenskap , Avdelningen för molekylärmedicin och genterapi and Internmedicin - epidemiologi
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin sig...
Alternative Titles
Full title
A Central Role for GRB10 in Regulation of Islet Function in Man
Authors, Artists and Contributors
Author / Creator
Poon, Wenny
Mägi, Reedik
Prasad B, Rashmi
Salehi, S. Albert
Almgren, Peter
Osmark, Peter
Bouatia-Naji, Nabila
Wierup, Nils
Fall, Tove
Stančáková, Alena
Barker, Adam
Lagou, Vasiliki
Osmond, Clive
Xie, Weijia
Lahti, Jari
Jackson, Anne U.
Cheng, Yu-Ching
Liu, Jie
O'Connell, Jeffrey R.
Blomstedt, Paul A.
Fadista, Joao
Alkayyali, Sami
Dayeh, Tasnim
Ahlqvist, Emma
Taneera, Jalal
Lecoeur, Cecile
Kumar, Ashish
Hansson, Ola
Hansson, Karin
Voight, Benjamin F.
Kang, Hyun Min
Levy-Marchal, Claire
Vatin, Vincent
Palotie, Aarno
Syvänen, Ann-Christine
Mari, Andrea
Weedon, Michael N.
Loos, Ruth J. F.
Ong, Ken K.
Nilsson, Peter
Isomaa, Bo
Tuomi, Tiinamaija
Wareham, Nicholas J.
Stumvoll, Michael
Widen, Elisabeth
Lakka, Timo A.
Langenberg, Claudia
Tönjes, Anke
Rauramaa, Rainer
Kuusisto, Johanna
Frayling, Timothy M.
Froguel, Philippe
Walker, Mark
Eriksson, Johan G.
Ling, Charlotte
Kovacs, Peter
Ingelsson, Erik
McCarthy, Mark I.
Shuldiner, Alan R.
Silver, Kristi D.
Laakso, Markku
Groop, Leif
Lyssenko, Valeriya
Strategiska forskningsområden (SFO)
Translationell muskelforskning
Department of Experimental Medical Science
Neuroendocrine Cell Biology
Department of Laboratory Medicine
EpiHealth: Epidemiology for Health
Diabetes - epigenetik
Strategic research areas (SRA)
Lund University
EXODIAB: Excellence of Diabetes Research in Sweden
Institutionen för laboratoriemedicin
Profile areas and other strong research environments
Department of Clinical Sciences, Malmö
Neuroendokrin cellbiologi
Faculty of Medicine
Medicinska fakulteten
Diabetes - Epigenetics
Institutionen för kliniska vetenskaper, Malmö
Internal Medicine - Epidemiology
Lunds universitet
Translational Muscle Research
Profilområden och andra starka forskningsmiljöer
Division of Molecular Medicine and Gene Therapy
Institutionen för experimentell medicinsk vetenskap
Avdelningen för molekylärmedicin och genterapi
Internmedicin - epidemiologi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1525304102
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1525304102
Other Identifiers
ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1004235
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