Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1...
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Lipotoxicity refers to cellular dysfunctions caused by elevated free fatty acid levels playing a central role in the development and progression of obesity related diseases. Saturated fatty acids cause insulin resistance and reduce insulin production in the pancreatic islets, thereby generating a vicious cycle, which potentially culminates in type...
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Full title
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells
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TN_cdi_plos_journals_1532653386
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1532653386
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0097868
