Development of a Novel Multiplex PCR Assay to Detect Functional Subtypes of KIR3DL1 Alleles
Development of a Novel Multiplex PCR Assay to Detect Functional Subtypes of KIR3DL1 Alleles
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Among NK cell receptor-ligand partnerships, KIR3DL1 and HLA-Bw4 demonstrate the greatest diversity; permutations of their allelic combinations titrate NK reactivity. Balancing selection has maintained distinct subtypes of KIR3DL1 alleles in global populations, implying that each may provide unique fitness advantages and variably influence disease p...
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Full title
Development of a Novel Multiplex PCR Assay to Detect Functional Subtypes of KIR3DL1 Alleles
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TN_cdi_plos_journals_1535002979
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1535002979
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0099543
