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Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Em...

Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Em...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1536053415

Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

About this item

Full title

Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

Publisher

United States: Public Library of Science

Journal title

PLoS genetics, 2014-05, Vol.10 (5), p.e1004317-e1004317

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that these retained histones provide epigenetic inform...

Alternative Titles

Full title

Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1536053415

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1536053415

Other Identifiers

ISSN

1553-7404,1553-7390

E-ISSN

1553-7404

DOI

10.1371/journal.pgen.1004317

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