Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Em...
Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression
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United States: Public Library of Science
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English
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United States: Public Library of Science
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To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that these retained histones provide epigenetic inform...
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Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression
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TN_cdi_plos_journals_1536053415
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1536053415
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1553-7404,1553-7390
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1553-7404
DOI
10.1371/journal.pgen.1004317