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Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaff...

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaff...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1544135952

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

About this item

Full title

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

Publisher

United States: Public Library of Science

Journal title

PloS one, 2014-07, Vol.9 (7), p.e101846-e101846

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Protein Phosphatase 2A (PP2A) is a major Ser/Thr phosphatase involved in the regulation of various cellular processes. PP2A assembles into diverse trimeric holoenzymes, which consist of a scaffolding (A) subunit, a catalytic (C) subunit and various regulatory (B) subunits. Here we report a 2.0 Å crystal structure of the free B''/PR70 subunit and a...

Alternative Titles

Full title

Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1544135952

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1544135952

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0101846