Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53...
Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells
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Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Experimental evolution has been used for various biotechnological applications including protein and microbial cell engineering, but less commonly in the field of oncolytic virotherapy. Here, we sought to adapt a rapidly evolving RNA virus to cells deficient for the tumor suppressor gene p53, a hallmark of cancer cells. To achieve this goal, we est...
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Full title
Experimental Evolution of an Oncolytic Vesicular Stomatitis Virus with Increased Selectivity for p53-Deficient Cells
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TN_cdi_plos_journals_1544377325
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1544377325
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0102365
