The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packa...
The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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The viral integrase (IN) is an essential protein for HIV-1 replication. IN inserts the viral dsDNA into the host chromosome, thereby aided by the cellular co-factor LEDGF/p75. Recently a new class of integrase inhibitors was described: allosteric IN inhibitors (ALLINIs). Although designed to interfere with the IN-LEDGF/p75 interaction to block HIV...
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Full title
The Allosteric HIV-1 Integrase Inhibitor BI-D Affects Virion Maturation but Does Not Influence Packaging of a Functional RNA Genome
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TN_cdi_plos_journals_1549286738
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1549286738
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0103552
