Enhanced Anti-Tumor Effect of Zoledronic Acid Combined with Temozolomide against Human Malignant Gli...
Enhanced Anti-Tumor Effect of Zoledronic Acid Combined with Temozolomide against Human Malignant Glioma Cell Expressing O6-Methylguanine DNA Methyltransferase
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Temozolomide (TMZ), a DNA methylating agent, is widely used in the adjuvant treatment of malignant gliomas. O6-methylguanine-DNA methyltranferase (MGMT), a DNA repair enzyme, is frequently discussed as the main factor that limits the efficacy of TMZ. Zoledronic acid (ZOL), which is clinically applied to treat cancer-induced bone diseases, appears t...
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Full title
Enhanced Anti-Tumor Effect of Zoledronic Acid Combined with Temozolomide against Human Malignant Glioma Cell Expressing O6-Methylguanine DNA Methyltransferase
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TN_cdi_plos_journals_1552644667
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1552644667
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0104538
