A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels
A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
γ-Aminobutyric acid type A receptors (GABAA receptors) are chloride ion channels composed of five subunits, mediating fast synaptic and tonic inhibition in the mammalian brain. These receptors show near five-fold symmetry that is most pronounced in the second trans-membrane domain M2 lining the Cl- ion channel. To take advantage of this inherent sy...
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Full title
A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels
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TN_cdi_plos_journals_1559783983
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1559783983
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0106688
