The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Activation of interstitial myofibroblasts and excessive production of extracellular matrix proteins are common pathways that contribute to chronic kidney disease. In a number of tissues, AMP-activated kinase (AMPK) activation has been shown to inhibit fibrosis. Here, we examined the inhibitory effect of the AMPK activator, 5-aminoimidazole-4-carbox...
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Full title
The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
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TN_cdi_plos_journals_1560108625
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1560108625
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0106554
