Activation of Cre recombinase alone can induce complete tumor regression
Activation of Cre recombinase alone can induce complete tumor regression
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The Cre/loxP system is a powerful tool for generating conditional genomic recombination and is often used to examine the mechanistic role of specific genes in tumorigenesis. However, Cre toxicity due to its non-specific endonuclease activity has been a concern. Here, we report that tamoxifen-mediated Cre activation in vivo induced the regression of...
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Full title
Activation of Cre recombinase alone can induce complete tumor regression
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TN_cdi_plos_journals_1561282802
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1561282802
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0107589
