A New IRAK-M-Mediated Mechanism Implicated in the Anti-Inflammatory Effect of Nicotine via α7 Nicoti...
A New IRAK-M-Mediated Mechanism Implicated in the Anti-Inflammatory Effect of Nicotine via α7 Nicotinic Receptors in Human Macrophages
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Nicotine stimulation of α7 nicotinic acetylcholine receptor (α7 nAChR) powerfully inhibits pro-inflammatory cytokine production in lipopolysaccharide (LPS)-stimulated macrophages and in experimental models of endotoxemia. A signaling pathway downstream from the α7 nAChRs, which involves the collaboration of JAK2/STAT3 and NF-κB to interfere with si...
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Full title
A New IRAK-M-Mediated Mechanism Implicated in the Anti-Inflammatory Effect of Nicotine via α7 Nicotinic Receptors in Human Macrophages
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TN_cdi_plos_journals_1565690286
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1565690286
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0108397
