Suramin inhibits Hsp104 ATPase and disaggregase activity
Suramin inhibits Hsp104 ATPase and disaggregase activity
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Hsp104 is a hexameric AAA+ protein that utilizes energy from ATP hydrolysis to dissolve disordered protein aggregates as well as amyloid fibers. Interestingly, Hsp104 orthologues are found in all kingdoms of life except animals. Thus, Hsp104 could represent an interesting drug target. Specific inhibition of Hsp104 activity might antagonize non-meta...
Alternative Titles
Full title
Suramin inhibits Hsp104 ATPase and disaggregase activity
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1609503613
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1609503613
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0110115
