Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by...
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Hypoxia-inducible factor 1α (HIF-1α), a major mediator of tumor physiology, is activated during tumor progression, and its abundance is correlated with therapeutic resistance in a broad range of solid tumors. The accumulation of HIF-1α is mainly caused by hypoxia or through the mutated succinate dehydrogenase A (SDHA) or fumarate hydratase (FH) exp...
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Full title
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2
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TN_cdi_plos_journals_1627711363
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1627711363
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0113865
