PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma
PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Resistance to apoptosis is a paramount issue in the treatment of Glioblastoma (GBM). We show that targeting PARP by the small molecule inhibitors, Olaparib (AZD-2281) or PJ34, reduces proliferation and lowers the apoptotic threshold of GBM cells in vitro and in vivo.
The sensitizing effects of PARP inhibition on TRAIL-mediated apoptosis and pote...
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PARP inhibition restores extrinsic apoptotic sensitivity in glioblastoma
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TN_cdi_plos_journals_1639491065
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1639491065
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0114583
