Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in pat...
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT) can predict the development of cisplatin-induced ototoxicity and may explain interindividual varia...
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Full title
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts
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TN_cdi_plos_journals_1641245289
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1641245289
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0115869
