Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phospho...
Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Signaling by the Gβγ subunit of Gi protein, leading to downstream c-Src-induced activation of the Ras/c-Raf1/MEK-ERK1/2 signaling pathway and its upregulation of phosphodiesterase-4 (PDE4) activity, was recently shown to mediate the heightened contractility in proasthmatic sensitized isolated airway smooth muscle (ASM), as well as allergen-induced...
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Full title
Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells
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TN_cdi_plos_journals_1660924550
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1660924550
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0118712
