Post-PKS Tailoring Steps of a Disaccharide-Containing Polyene NPP in Pseudonocardia autotrophica
Post-PKS Tailoring Steps of a Disaccharide-Containing Polyene NPP in Pseudonocardia autotrophica
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United States: Public Library of Science
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English
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United States: Public Library of Science
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A novel polyene compound NPP identified in a rare actinomycetes, Pseudonocardia autotrophica KCTC9441, was shown to contain an aglycone identical to nystatin but to harbor a unique di-sugar moiety, mycosaminyl-(α1-4)-N-acetyl-glucosamine, which led to higher solubility and reduced hemolytic activity. Although the nppDI was proved to be responsible...
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Post-PKS Tailoring Steps of a Disaccharide-Containing Polyene NPP in Pseudonocardia autotrophica
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TN_cdi_plos_journals_1671015644
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1671015644
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0123270
