The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response...
The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled receptor ORF74. Although ORF74 is constitutively active, it binds human CXC chemokines that modulate this basal activity. ORF74-induced signaling has been demonstrated to underlie the development of the angioproliferative tumor Kaposi's sarcoma. Whe...
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Full title
The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines
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TN_cdi_plos_journals_1674451910
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1674451910
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0124486
