Structural Dynamics of the Cereblon Ligand Binding Domain
Structural Dynamics of the Cereblon Ligand Binding Domain
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Cereblon, a primary target of thalidomide and its derivatives, has been characterized structurally from both bacteria and animals. Especially well studied is the thalidomide binding domain, CULT, which shows an invariable structure across different organisms and in complex with different ligands. Here, based on a series of crystal structures of a b...
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Full title
Structural Dynamics of the Cereblon Ligand Binding Domain
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TN_cdi_plos_journals_1684191935
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1684191935
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0128342
