The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects
The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell's proliferative ability, or cellular fitness, has remained elusive. In this study, we have combined a detailed analysis of aneuploid clones isolated from laboratory-evolved populations of Saccharomyces cerevisiae with a systematic, genome-wide sc...
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The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects
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TN_cdi_plos_journals_1685027032
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685027032
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1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.1002155
