Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and l...
Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked out in osteoclasts. Endocytosis is severely defecti...
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Osteopetrorickets due to Snx10 deficiency in mice results from both failed osteoclast activity and loss of gastric acid-dependent calcium absorption
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TN_cdi_plos_journals_1685141073
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685141073
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ISSN
1553-7404,1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1005057
