Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in...
Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis
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Author / Creator
Amaral, Eduardo P. , Ribeiro, Simone C. M. , Lanes, Verônica R. , Almeida, Fabrício M. , de Andrade, Marcelle R. M. , Bomfim, Caio Cesar Barbosa , Salles, Érika M. , Bortoluci, Karina R. , Coutinho-Silva, Robson , Hirata, Mario H. , Alvarez, José M. , Lasunskaia, Elena B. and D'Império-Lima, Maria Regina
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Contents
The purinergic P2X7 receptor (P2X7R) is a sensor of extracellular ATP, a damage-associated molecule that is released from necrotic cells and that induces pro-inflammatory cytokine production and cell death. To investigate whether the innate immune response to damage signals could contribute to the development of pulmonary necrotic lesions in severe...
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Full title
Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis
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TN_cdi_plos_journals_1685148320
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685148320
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1004188
