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Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Asperg...

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Asperg...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685210030

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

About this item

Full title

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2014-09, Vol.10 (9), p.e1004378

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Hypoxia inducible factor 1α (HIF1α) is the mammalian transcriptional factor that controls metabolism, survival, and innate immunity in response to inflammation and low oxygen. Previous work established that generation of hypoxic microenvironments occurs within the lung during infection with the human fungal pathogen Aspergillus fumigatus. Here we d...

Alternative Titles

Full title

Myeloid Derived Hypoxia Inducible Factor 1-alpha Is Required for Protection against Pulmonary Aspergillus fumigatus Infection

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1685210030

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1685210030

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1004378

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