Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations...
Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes
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Author / Creator
Tong, Xin , Zhang, Deqiang , Arthurs, Blake , Li, Pei , Durudogan, Leigh , Gupta, Neil and Yin, Lei
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
Elevated levels of serum saturated fatty acid palmitate have been shown to promote insulin resistance, increase cellular ROS production, and trigger cell apoptosis in hepatocytes during the development of obesity. However, it remains unclear whether palmitate directly impacts the circadian clock in hepatocytes, which coordinates nutritional inputs...
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Full title
Palmitate Inhibits SIRT1-Dependent BMAL1/CLOCK Interaction and Disrupts Circadian Gene Oscillations in Hepatocytes
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TN_cdi_plos_journals_1688547659
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1688547659
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0130047
