Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
About this item
Full title
Author / Creator
Publisher
United States: Public Library of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: Public Library of Science
Subjects
More information
Scope and Contents
Contents
Patients with type 1 diabetes (T1D) suffer from beta-cell destruction by CD8+ T-cells that have preproinsulin as an important target autoantigen. It is of great importance to understand the molecular mechanism underlying the processing of preproinsulin into these CD8+ T-cell epitopes. We therefore studied a pathway that may contribute to the produc...
Alternative Titles
Full title
Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1691040439
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1691040439
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0128206
