Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing ra...
Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing rats
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The tyrosine kinase (TK) inhibitor imatinib provides a highly effective therapy for chronic myeloid leukemia (CML) via inhibition of the oncogenic TK BCR-ABL1. However, off-target TKs like platelet-derived growth factor receptors (PDGF-R) and colony-stimulating factor-1 receptor (c-fms), involved in bone remodeling, are also inhibited. Thus, pediat...
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Full title
Impact of long-term exposure to the tyrosine kinase inhibitor imatinib on the skeleton of growing rats
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TN_cdi_plos_journals_1691043108
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1691043108
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0131192
