Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regu...
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, little is known regarding factors that regulate CTLA-4 expression and their effect upon its function...
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Full title
Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function
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TN_cdi_plos_journals_1693189153
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1693189153
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0131539
