Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and I...
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy
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Author / Creator
Dorywalska, Magdalena , Strop, Pavel , Melton-Witt, Jody A , Hasa-Moreno, Adela , Farias, Santiago E , Galindo Casas, Meritxell , Delaria, Kathy , Lui, Victor , Poulsen, Kris , Sutton, Janette , Bolton, Gary , Zhou, Dahui , Moine, Ludivine , Dushin, Russell , Tran, Thomas-Toan , Liu, Shu-Hui , Rickert, Mathias , Foletti, Davide , Shelton, David L , Pons, Jaume and Rajpal, Arvind
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
The efficacy of an antibody-drug conjugate (ADC) is dependent on the properties of its linker-payload which must remain stable while in systemic circulation but undergo efficient processing upon internalization into target cells. Here, we examine the stability of a non-cleavable Amino-PEG6-based linker bearing the monomethyl auristatin D (MMAD) pay...
Alternative Titles
Full title
Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy
Authors, Artists and Contributors
Author / Creator
Strop, Pavel
Melton-Witt, Jody A
Hasa-Moreno, Adela
Farias, Santiago E
Galindo Casas, Meritxell
Delaria, Kathy
Lui, Victor
Poulsen, Kris
Sutton, Janette
Bolton, Gary
Zhou, Dahui
Moine, Ludivine
Dushin, Russell
Tran, Thomas-Toan
Liu, Shu-Hui
Rickert, Mathias
Foletti, Davide
Shelton, David L
Pons, Jaume
Rajpal, Arvind
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Primary Identifiers
Record Identifier
TN_cdi_plos_journals_1695377981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1695377981
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0132282
