Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-...
Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Human pluripotent stem cell-derived hepatocytes have the potential to provide in vitro model systems for drug discovery and hepatotoxicity testing. However, these cells are currently unsuitable for drug toxicity and efficacy testing because of their limited expression of genes encoding drug-metabolizing enzymes, especially cytochrome P450 (CYP) enz...
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Full title
Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes
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TN_cdi_plos_journals_1696689463
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1696689463
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0132992
