Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of...
Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp
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Author / Creator
Zhao, Minzhi , Lei, Chunni , Yang, Yadong , Bu, Xiangli , Ma, Huailei , Gong, He , Liu, Juan , Fang, Xiangdong , Hu, Zhiyuan and Fang, Qiaojun
Publisher
United States: Public Library of Science
Journal title
Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
P-glycoprotein (P-gp) can actively pump paclitaxel (PTX) out of cells and induces drug resistance. Abraxane, a nanoparticle (NP) formulation of PTX, has multiple clinical advantages over the single molecule form. However, it is still unclear whether Abraxane overcomes the common small molecule drug resistance problem mediated by P-gp. Here we were...
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Full title
Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp
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Record Identifier
TN_cdi_plos_journals_1696884785
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1696884785
Other Identifiers
ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0131429
