Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modula...
Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups
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United States: Public Library of Science
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English
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United States: Public Library of Science
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Brain gene transfer using viral vectors will likely become a therapeutic option for several disorders. Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal. These vectors are poorly immunogenic, efficiently transduce neurons, are retrogradely transported to afferent structures in the brain and lead to long-te...
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Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups
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TN_cdi_plos_journals_1698612284
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1698612284
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0133607
