Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebr...
Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND). Patients with severe mutations also suffer from neurological complications. Glibenclamide blocks the open KATP channels and is the treatment of choice for ND. However, although glibenclamide successfully restores normoglycaemia,...
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Full title
Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents
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TN_cdi_plos_journals_1700336680
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1700336680
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0134476
