Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Se...
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
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Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Scope and Contents
Contents
A hallmark of the gluten-driven enteropathy celiac disease is autoantibody production towards the enzyme transglutaminase 2 (TG2) that catalyzes the formation of covalent protein-protein cross-links. Activation of TG2-specific B cells likely involves gluten-specific CD4 T cells as production of the antibodies is dependent on disease-associated HLA-...
Alternative Titles
Full title
Enhanced B-Cell Receptor Recognition of the Autoantigen Transglutaminase 2 by Efficient Catalytic Self-Multimerization
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TN_cdi_plos_journals_1701896314
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1701896314
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0134922
