Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis...
Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
The tumor microenvironment is characterized by regions of hypoxia and acidosis which are linked to poor prognosis. This occurs due to an aberrant vasculature as well as high rates of glycolysis and lactate production in tumor cells even in the presence of oxygen (the Warburg effect), which weakens the spatial linkage between hypoxia and acidosis.
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Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro
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TN_cdi_plos_journals_1704063007
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1704063007
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0134955
