Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Transplantation of glioblastoma patient biopsy spheroids to the brain of T cell-compromised Rowett (nude) rats has been established as a representative animal model for human GBMs, with a tumor take rate close to 100%. In immunocompetent littermates however, primary human GBM tissue is invariably rejected. Here we show that after repeated passaging...
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Full title
Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired Immunosuppression
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TN_cdi_plos_journals_1708482793
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1708482793
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0136089
