Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export...
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma characterized by the aberrant expression of several growth-regulating, oncogenic effectors. Exportin 1 (XPO1) mediates the nucleocytoplasmic transport of numerous molecules including oncogenic growth-regulating factors, RNAs, and ribosomal subunits. In MCL cells, the small molecule KPT-185...
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Full title
Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185
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TN_cdi_plos_journals_1719271382
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1719271382
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0137210
