A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation...
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
Certain missense mutations in optineurin/OPTN and amplification of TBK1 are associated with normal tension glaucoma. A glaucoma-associated variant of OPTN, M98K, induces autophagic degradation of transferrin receptor (TFRC) and death in retinal cells. Here, we have explored the role of Tbk1 in M98K-OPTN-induced autophagy and cell death, and the eff...
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Full title
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin
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TN_cdi_plos_journals_1719285731
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1719285731
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0138289
