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Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fun...

Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fun...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1719288673

Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

About this item

Full title

Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

Publisher

United States: Public Library of Science

Journal title

PloS one, 2015-09, Vol.10 (9), p.e0138291-e0138291

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Type I interferons (IFNs) are secreted by many cell types upon stimulation via pattern recognition receptors and bind to IFN-α/β receptor (IFNAR), which is composed of IFNAR1 and IFNAR2. Although type I IFNs are well known as anti-viral cytokines, limited information is available on their role during fungal infection. In the present study, we addre...

Alternative Titles

Full title

Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1719288673

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1719288673

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0138291

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