Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralizati...
Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies
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United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Contents
HIV-1 envelope glycoproteins (Env) are the only viral antigens present on the virus surface and serve as the key targets for virus-neutralizing antibodies. However, HIV-1 deploys multiple strategies to shield the vulnerable sites on its Env from neutralizing antibodies. The V1V2 domain located at the apex of the HIV-1 Env spike is known to encompas...
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Full title
Rationally Targeted Mutations at the V1V2 Domain of the HIV-1 Envelope to Augment Virus Neutralization by Anti-V1V2 Monoclonal Antibodies
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TN_cdi_plos_journals_1725480900
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1725480900
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0141233
