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Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Dat...

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Dat...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1727646851

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse

About this item

Full title

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse

Publisher

United States: Public Library of Science

Journal title

PloS one, 2015-10, Vol.10 (10), p.e0141136-e0141136

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

The muscarinic M2 receptor (M2R) acts as a negative feedback regulator in central cholinergic systems. Activation of the M2 receptor limits acetylcholine (ACh) release, especially when ACh levels are increased because acetylcholinesterase (AChE) activity is acutely inhibited. Chronically high ACh levels in the extracellular space, however, were rep...

Alternative Titles

Full title

Dysfunctional Presynaptic M2 Receptors in the Presence of Chronically High Acetylcholine Levels: Data from the PRiMA Knockout Mouse

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1727646851

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1727646851

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0141136

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