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Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1732577577

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

About this item

Full title

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Publisher

United States: Public Library of Science

Journal title

PloS one, 2015-11, Vol.10 (11), p.e0142902-e0142902

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6...

Alternative Titles

Full title

Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_plos_journals_1732577577

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1732577577

Other Identifiers

ISSN

1932-6203

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0142902

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