Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniqui...
Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine
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Author / Creator
Taylor, Alexander B , Pica-Mattoccia, Livia , Polcaro, Chiara M , Donati, Enrica , Cao, Xiaohang , Basso, Annalisa , Guidi, Alessandra , Rugel, Anastasia R , Holloway, Stephen P , Anderson, Timothy J C , Hart, P John , Cioli, Donato , LoVerde, Philip T and Argonne National Laboratory (ANL), Argonne, IL (United States)
Publisher
United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Contents
For over two decades, a racemic mixture of oxamniquine (OXA) was administered to patients infected by Schistosoma mansoni, but whether one or both enantiomers exert antischistosomal activity was unknown. Recently, a ~30 kDa S. mansoni sulfotransferase (SmSULT) was identified as the target of OXA action.
Here, we separate the OXA enantiomers usin...
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Full title
Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine
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TN_cdi_plos_journals_1733646103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1733646103
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ISSN
1935-2735,1935-2727
E-ISSN
1935-2735
DOI
10.1371/journal.pntd.0004132
