CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
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Author / Creator
Gupta, Prakash K. , Godec, Jernej , Wolski, David , Adland, Emily , Yates, Kathleen , Pauken, Kristen E. , Cosgrove, Cormac , Ledderose, Carola , Junger, Wolfgang G. , Robson, Simon C. , Wherry, E. John , Alter, Galit , Goulder, Philip J. R. , Klenerman, Paul , Sharpe, Arlene H. , Lauer, Georg M. and Haining, W. Nicholas
Publisher
United States: Public Library of Science
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Language
English
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Publisher
United States: Public Library of Science
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Scope and Contents
Contents
Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a marker of exhausted CD8+ T cells. CD8+ T cells spe...
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Full title
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells
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TN_cdi_plos_journals_1733657859
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1733657859
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ISSN
1553-7374,1553-7366
E-ISSN
1553-7374
DOI
10.1371/journal.ppat.1005177
